It begins the day after next year in California. A maladjusted computer industry billionaire and a somewhat crazy US president initiate a radical transformation of the world through sentient nanotechnology; sort of the equivalent of biological artificial intelligence. At first they succeed, but their plans are reversed by Chu, an autistic boy.
The next time it isn't so easy to stop them. Most of the story takes place in our world after a previously unimaginable transformation. All things look the same, and all people feel the samebut they are different (they're able to read each others' minds, for starters).
Travel to and from other nearby worlds in the quantum universe is possible. And our world is visited by giant humanoids from another quantum universe, some of whom mean to tidy up the mess we've made. Or maybe just run things.